GHK-Cu Tripeptide — Stability Data Summary

GHK-Cu (Glycyl-L-Histidyl-L-Lysine copper(II) complex) is among the most studied tripeptides in dermatological research. Below is a stability data summary across four sequential production lots.

Compound Identity

Sequence: H-Gly-His-Lys-OH · Cu(II). Molecular formula C14H22CuN6O4. Calculated MW 401.91. Observed [M+H]+ by ESI-MS: 402.1 ± 0.5.

Lot Purity (HPLC, 220 nm)

Lot	Released	Purity (T0)	Purity (90 d)
2025-09-002	2025-09-15	99.4%	99.3%
2025-10-004	2025-10-08	99.2%	99.1%
2025-11-001	2025-11-04	99.5%	99.4%
2025-12-003	2025-12-17	99.3%	99.2%

Storage Conditions

Lyophilized vials stored at −20 °C, desiccated, sealed. 90-day reassay performed on retain samples held under identical conditions.

Conclusion

GHK-Cu shows excellent storage stability under cold-chain conditions, with <0.2% loss over 90 days. Reconstituted solution should be used within 21 days when stored at 2–8 °C.

RUO. Internal lot summary; not a clinical specification.